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2025-10-03口腔健康北京实验室王松灵院士/附属朝阳医院张栋教授/孙广永副教授团队揭示硝酸盐-Sialin调控免疫稳态防治代...
2025-10-03开云研究生在2025京津冀创新医学转化大赛中展示成果
2025-10-01开云3位教授荣获第六届北京市华侨华人“京华奖”
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2025-09-30开云kaiyun官方网站医学技术学院揭牌成立！
2025-09-30开云康复物理治疗专业成功通过WPT国际教育复认证
2025-09-292025年区属医院领导人员管理能力提升专题研讨班结业仪式在开云圆满举行
2025-09-27开云kaiyun官方网站临床检验中心大兴新址正式投入运营
2025-09-26开云kaiyun官方网站召开“十五五”规划编制工作进展情况汇报会

王硕等（天坛医院）JAMA NEUROLOGY --Gadolinium-Enhanced Aneurysm Wall Imaging and Risk of Intracranial Aneurysm Growth or Rupture
郭力嘉/刘怡等（口腔医院）Bioactive Materials --Mechanism and regulatory strategy study on promoting vascularized bone
regeneration via intracellular zinc ion transport
李玉琳等（安贞医院）Immunity --Optogenetic vagal nerve stimulation attenuates heart
failure by limiting the generation f monocyte-derived
inflammatory CCRL2+ macrophages
邢卉春/王玺等（地坛医院）Gut Microbes --Gut microbial metabolite butyrate suppresses
hepatocellular carcinoma growth via CXCL11-
dependent enhancement of natural killer cell
infiltration
卢洁/唐毅等（宣武医院）Radiology --Modulation of Cortical and Hippocampal Functional MRI
Connectivity Following Transcranial Alternating Current
Stimulation in Mild Alzheimer Disease
金子兵等（同仁医院）Science Bulletin --Juvenile macular degeneration in nonhuman primates generated by
germline knockout of ABCA4 gene
王刚/闫芳等（安定医院）npj Digital Medicine --Randomized clinical trial of a digital
medication system to enhance adherence
in patients with severe mental disorders
孙英/王炜等（基础医学院）Advanced Science --Neutrophil–Endothelium Interaction Mediated by S100A9 Promotes Pulmonary Vascular Remodeling During
Pulmonary Hypertension
梁庆丰等（同仁医院）eBioMedicine --Bifunctional chemokine-nanobody fusion protein enhances neutrophil recruitment to impede Acanthamoeba immune
evasion
王刚/杜静等（安定医院）npj Science of Food --Long-term GABA supplementation
mitigates anxiety by modulating
complement and neuroinflammatory
pathways
唐毅等（宣武医院）Science Bulletin --Coupled sleep rhythm disruption predicts cognitive decline in
Alzheimer's disease
刘磊等（基础医学院）Nature Communications --A TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption
王松灵等（基础医学院）PNAS --An atlas of early human mandibular endochondral
and osteogenic paracrine signaling regions of Meckel’s cartilage
王松灵等（基础医学院）Cell Reports --Integrated multi-omics profiling characterizes the crucial role of human dental epithelium during tooth development
闫致强等（基础医学院）Neuron --TMEM63B functions as a mammalian hyperosmolar
sensor for thirst
王松灵等（基础医学院）Science Bulletin --Nitrate ameliorates myelin loss and cognitive impairment in Alzheimer’s
disease through upregulation of neuronal sialin and subsequent
inhibition of TPPP phosphorylation
张晨/王伟/刘希成等（基础医学院）Cell Metabolism --Microbiota-derived lysophosphatidylcholine
alleviates Alzheimer’s disease pathology via
suppressing ferroptosis
卢洁/武力勇等（宣武医院）Neurology --Association of Glymphatic Function With Clinical
Characteristics in Patients With Clinical and Asymptomatic Creutzfeldt-Jakob Disease
刘静等（安贞医院）Nature Communications --Effectiveness of treat-to-target cholesterollowering
interventions on cardiovascular
disease and all-cause mortality risk in the
community-dwelling population: a target
trial emulation
王伟等（基础医学院）Gut Microbes --B. vulgatus ameliorates high-fat diet-induced obesity through modulating
intestinal serotonin synthesis and lipid absorption in mice
赵继宗/王硕等（天坛医院）LANCET NEUROLOGY --Safety and efficacy of early versus delayed acetylsalicylic acid
after surgery for spontaneous intracerebral haemorrhage
in China (E-start): a prospective, multicentre, open-label,
blinded-endpoint, randomised trial
李子孝等（天坛医院）INNOVATION --Beyond low-density lipoprotein cholesterol levels: Impact of prior statin treatment on ischemic stroke outcomes
张宏伟等（三博脑科医院）Nature Communications --Non-secreting IL12 expressing oncolytic
adenovirus Ad-TD-nsIL12 in recurrent highgrade glioma: a phase I trial
吴若嘉等（药学院）Nature Communications --Longitudinal ultra-sensitive mutation
burden sequencing for precise minimal residual disease assessment in AML
马长生等（安贞医院）JAMA --Pulmonary Vein Isolation With Optimized Linear Ablation vs Pulmonary Vein Isolation Alone for Persistent AF The PROMPT-AF Randomized Clinical Trial
王雅杰等（地坛医院）Journal of Infection --Synergistic evolution: The dynamic adaptation of SARS-CoV-2 and
human protective immunity in the real world
洪韬/张鸿祺等（宣武医院）The American Journal of Human Genetics --GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas
逄宇等（胸科医院）Cell Mol Immunol --Kynurenine-AhR reduces T-cell infiltration and induces a delayed T-cell immune response by suppressing the STAT1-CXCL9/CXCL10 axis in tuberculosis
刘亚欧等（天坛医院）Brain --Distinct virtual histology of grey matter atrophy in four neuroinflammatory diseases
武力勇等（宣武医院）JAMA Neurology --Multisite Skin Biopsies vs Cerebrospinal Fluid for Prion Seeding Activity in the Diagnosis of Prion Diseases
王刚/周佳等（安定医院）Brain Stimulation --Effect of add-on transcranial alternating current stimulation (tACS) in major depressive disorder: A randomized controlled trial
王刚/杨健等（安定医院）Advanced Science --Integrated Single-Cell RNA-seq and ATAC-seq Reveals
Heterogeneous Differentiation of CD4+ Naive T Cell
Subsets is Associated with Response to Antidepressant
Treatment in Major Depressive Disorder
冯涛等（天坛医院）Neurology --Distinctive Pattern of Metal Deposition in Neurologic
Wilson Disease
阴赪宏等（妇产医院）Environmental Science & Technology --Associations of Ambient Particulate Matter with Maternal Thyroid
Autoimmunity and Thyroid Function in Early Pregnancy
吴燕等（基础医学院）PNAS --Bispecific antibodies targeting two glycoproteins on SFTSV
exhibit synergistic neutralization and protection in a
mouse model
马伟等（基础医学院）Redox Biology --Iron accumulation in ovarian microenvironment damages the local redox
balance and oocyte quality in aging mice
冯涛等（天坛医院）Science Advances --Molecular beacon–based detection of circulating
microRNA-containing extracellular vesicle as an α-synucleinopathy biomarker
王伊龙/王拥军等（天坛医院）JAMA Neurology --Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia The INSPIRES Randomized Clinical Trial
张建国等（天坛医院）JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY --Contribution of basal ganglia activity to REM sleep disorder in Parkinson’s disease
李纤/杨菲等（基础医学院）Cell Death & Differentiation --Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke
王伽伯等（中医药学院）Journal of Advanced Research --Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2
洪韬等（宣武医院）Angiogenesis --Somatic Braf V600E mutation in the cerebral endothelium induces brain arteriovenous malformations
李玉琳等（安贞医院）ACS Nano --One Endothelium-Targeted Combined Nucleic Acid Delivery System for Myocardial Infarction Therapy
冯芝恩/韩正学等（口腔医院）Journal of Extracellular Vesicles --The small extracellular vesicle-mediated intercellular
transformation of CXCR1Low to CXCR1High tumour cells promotes the progression of head and neck squamous cell carcinoma
马伟等（基础医学院）Autophagy --PLD1 promotes spindle assembly and migration
through regulating autophagy in mouse oocyte meiosis
李长龙等（基础医学院）Gastric Cancer --Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6
阴赪宏等（妇产医院）Phytomedicine --Baicalein improves the symptoms of polycystic ovary syndrome by
mitigating oxidative stress and ferroptosis in the ovary and gravid placenta
柳柯等（友谊医院）ACS Nano --Complete Restoration of Hearing Loss and Cochlear Synaptopathy via Minimally
Invasive, Single-Dose, and Controllable Middle Ear Delivery of Brain-Derived Neurotrophic Factor−Poly(DL-lactic acid-coglycolic
acid)-Loaded Hydrogel
贾建平等（宣武医院）NEJM --Biomarker Changes during 20 Years
Preceding Alzheimer’s Disease
郭秀海等（宣武医院）BMC MED --Effects of acetazolamide combined with remote ischemic preconditioning on risk
of acute mountain sickness: a randomized
clinical trial
饶毅等（开云kaiyun官方网站）Sci Adv --Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute pancreatitis
贾旺等（天坛医院）NPJ Digit Med --Wireless facial biosensing system for monitoring facial palsy
with flexible microneedle electrode arrays
江涛等（天坛医院）Sig Transduct Target Ther --Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape
金子兵等（同仁医院）Elife --RNA fusion in human retinal development
李巍等（儿童医院）ATVB --Physical Contacts Between Mitochondria and WPBs Participate in WPB Maturation
石汉平等（世纪坛医院）JAMA Netw Open --New-Onset Age of Nonalcoholic Fatty Liver Disease and Cancer Risk
安静等（基础医学院）J Virol --Zika virus infection leads to hormone deficiencies of the hypothalamic-pituitary-gonadal axis and diminished fertility in mice
王拥军等（天坛医院）BMJ --Early versus delayed antihypertensive treatment in patients with acute ischaemic stroke: multicentre, open label, randomised, controlled trial
安静等（基础医学院）EBioMedicine --Neutrophil infiltration leads to fetal growth restriction by impairing the placental vasculature in DENV-infected pregnant mice
谷鸿秋等（天坛医院）Lancet Reg Health West Pac --Clinical characteristics, in-hospital management, and outcomes of patients with in-hospital vs. community-onset ischaemic stroke: a hospital-based cohort study
张澍田等（友谊医院）Am J Gastroenterol --Effect of 3-Dimensional Imaging Device on Polyp and Adenoma Detection During Colonoscopy: A Randomized Controlled Trial
张建国等（天坛医院）Nat Commun --Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance
曾辉等（世纪坛医院）Cell Rep --Sepsis induces non-classic innate immune memory in granulocytes
王刚等（安定医院）Microbiome --Multi‑omics reveal microbial determinants
impacting the treatment outcome
of antidepressants in major depressive disorder
马宁等（天坛医院）RADIOLOGY --New Diffusion Abnormalities Following Endovascular
Treatment for Intracranial Atherosclerosis
葛献鹏等（宣武医院）Elife --NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation
孔维军等（中医药学院）FOOD RES INT --Multi-mycotoxin detection and human exposure risk assessment in
medicinal foods
卢洁等（宣武医院）radiology --Deep Learning for Head and Neck CT Angiography: Stenosis and Plaque Classification
刘琰、饶毅等（基础医学院）Neuron --Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin

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